The mechanism of action of antibiotics. The reaction of unsaturated lactones with cysteine and related compounds

CJ Cavallito, TH Haskell

Index: Cavallito; Haskell Journal of the American Chemical Society, 1945 , vol. 67, p. 1991,1993

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Citation Number: 84

Abstract

A common property of many antibiotics which the enolized unsaturated structure which could transcends chemical structural relationships is add RSH. In order to cast more light on this that of being inactivated by means of cysteine subject, the reaction of certain lactones with amand certain related substances. It was suggested inothiols was investigated. that possibly the fundamental mode of action of The A'a@-and ABS?-angelicalactones were ...