New syntheses on the basis of ethyl 2-oxotetrahydrofuran-3-carboxylates

TV Kochikyan, EV Arutyunyan, VS Arutyunyan…

Index: Kochikyan; Arutyunyan; Avetisyan Russian Journal of Organic Chemistry, 2008 , vol. 44, # 6 p. 849 - 854

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Citation Number: 2

Abstract

Abstract Alkylation of 5-substituted ethyl 5-methyl-2-oxotetrahydrofuran-3-carboxylates with alkyl halides in the presence of sodium ethoxide gave the corresponding 3-alkyl derivatives which were converted into 3, 5-substituted 5-methyl-N-(4-nitrophenyl)-2-oxotetrahydrofuran- 3-carboxamides and 5-methyltetrahydrofuran-2-ones. Reactions of the latter with hydrazine hydrate led to the formation of 4-hydroxypentanoic acid hydrazides which were treated ...