Synlett

N-Heterocyclic carbenes of indazole as reagents: Indazol-3-ylidene-mediated syntheses of amidines from thiolactams of pyrrolobenzodiazepines

A Lindner, A Schmidt

Index: Lindner, Anika; Schmidt, Andreas Synlett, 2008 , # 19 p. 2961 - 2964

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Citation Number: 9

Abstract

Abstract On decarboxylation, 1, 2-dimethylindazolium-3-carboxylate forms in situ the N- heterocyclic carbene 1, 2-dimethylindazol-3-ylidene, which proved to be a suitable reagent for amidinations of the monothiolactam of benzo [e] pyrrolo [1, 2-a][1, 4] diazepine. A comparison of this metal-free approach to amidines to HgCl 2-and Bi (NO 3) 3-mediated reactions is presented.

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