Synthesis of new cytotoxic aminoanthraquinone derivatives via nucleophilic substitution reactions
…, MAHM Sukari, SSSA Azziz, WC Fah, H Alimon…
Index: Nor, Siti Mariam Mohd; Sukari, Mohd Aspollah Hj Md; Azziz, Saripah Salbiah Syed Abdul; Fah, Wong Chee; Alimon, Hasimah; Juhan, Siti Fadilah Molecules, 2013 , vol. 18, # 7 p. 8046 - 8062
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Citation Number: 6
Abstract
Abstract: Aminoanthraquinones were successfully synthesized via two reaction steps. 1, 4- Dihydroxyanthraquinone (1) was first subjected to methylation, reduction and acylation to give an excellent yield of anthracene-1, 4-dione (3), 1, 4-dimethoxyanthracene-9, 10-dione (5) and 9, 10-dioxo-9, 10-dihydroanthracene-1, 4-diyl diacetate (7). Treatment of 1, 3, 5 and 7 with BuNH 2 in the presence of PhI (OAc) 2 as catalyst produced seven ...
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