The use of aqueous potassium dichloroiodate for the synthesis of ureas

GM Viana, LC de Sequeira Aguiar, J de Araújo Ferrão…

Index: Viana, Gil Mendes; De Sequeira Aguiar, Lucia Cruz; De Araujo Ferrao, Jonas; Simas, Alessandro Bolis Costa; Vasconcelos, Marcela Guariento Tetrahedron Letters, 2013 , vol. 54, # 8 p. 936 - 940

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Citation Number: 11

Abstract

We report a straightforward and efficient reaction protocol for the syntheses of substituted ureas via treatment of thioureas with aqueous potassium dichloroiodate (KICl2). By tuning the reaction condition, thioureas bearing activated N-aryl substituents may undergo either selective oxidation or sequential oxidation and iodination, forming iodoaryl ureas in the latter case.

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