Synthesis of 3-substituted isocoumarins and their inhibitory effects on degranulation of RBL-2H3 cells induced by antigen
…, H Matsuda, M Yoshikawa, I Kawasaki, S Ohta
Index: Kurume, Ai; Kamata, Yasuhiro; Yamashita, Masayuki; Wang, Qilong; Matsuda, Hisashi; Yoshikawa, Masayuki; Kawasaki, Ikuo; Ohta, Shunsaku Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 9 p. 1264 - 1269
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Citation Number: 31
Abstract
Eleven 3-substituted isocoumarins and a benzylidenephthalide were synthesized through thermal cyclization reaction of δ-and γ-ketoamides, respectively. Subsequent deprotection of the hydroxyl groups of the resulting isocoumarin and benzylidenephthalide compounds afforded thunberginols A, B, and F, respectively, which originated from the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO. The synthesized ...
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