Efficient synthesis of purines and purine nucleosides via an inverse electron demand Diels-Alder reaction

Q Dang, Y Liu, MD Erion

Index: Dang, Qun; Liu, Yan; Erion, Mark D. Journal of the American Chemical Society, 1999 , vol. 121, # 24 p. 5833 - 5834

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Citation Number: 44

Abstract

Purine nucleosides represent an important class of therapeutically active agents and consequently a central focus of many drug discovery efforts. 1 Recently we became interested in the synthesis of 2-and 6-substituted purine nucleosides on the basis of theoretical calculations suggesting that certain substituents at these positions might promote hydration of the 1, 6-double bond and consequently enable inhibition of adenosine ...

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