Regioselective biotransformations of dinitriles using Rhodococcus sp. AJ270 1

O Meth-Cohn, MX Wang

Index: Meth-Cohn, Otto; Wang, Mei-Xiang Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3197 - 3204

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Citation Number: 67

Abstract

A variety of dinitriles have been hydrolysed selectively under very mild conditions using Rhodococcus sp. AJ270. Aliphatic dinitriles NC [CH2] nCN 1 undergo regioselective hydrolysis to give the mono acids 2 with up to 4 methylenes between the nitrile functions while those with n> 4 give the diacids 3 in good yield. Dinitriles NC [CH2] nX [CH2] nCN 4 bearing an ether or sulfide linkage are efficiently transformed into the mono acids 5 when ...