A New Synthesis of Flavone Involving Cyclization via Displacement of Aromatic Chlorine

PL Southwick, JR Kirchner

Index: Southwick; Kirchner Journal of the American Chemical Society, 1957 , vol. 79, p. 689

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Abstract

We wish to describe the results of the initial investigation of a new cyclization reaction which can be used for the preparation of flavone (VI) and probably will prove applicable to the synthesis of some types of substituted flavones. The cyclization in question occurs when P- morpholino-2-chlorochalcone (11) is heated to the proper ternperature in a solvent. The initial reaction product is not flavone itself but a related salt, 4-morpholinoflavyliurn ...