Journal of Heterocyclic Chemistry

Pyrimidines. XIV. Synthesis of 1??substituted 5, 6??dihydrocytosines and an improved synthesis of 1??substituted uracils

CC Cheng, LR Lewis

Index: Cheng,C.C.; Lewis,L.R. Journal of Heterocyclic Chemistry, 1964 , vol. 1, p. 260 - 262

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Citation Number: 10

Abstract

Abstract 1-Substituted 5, 6-dihydrouracils (VI) and 1-substituted 5, 6-dihydrocytosines (V) were prepared by cyclization of N-substituted N-β-cyanoethyl ureas (IV) in acid and basic medium, respectively. Compounds N were synthesized from cyanic acid and β-(substituted amino) propionitriles (III), the latter in turn were prepared from primary amines (I) and acrylonitrile (II).