Amidate ligand design effects in zirconium-catalyzed enantioselective hydroamination of aminoalkenes

RO Ayinla, T Gibson, LL Schafer

Index: Ayinla, Rashidat O.; Gibson, Travis; Schafer, Laurel L. Journal of Organometallic Chemistry, 2011 , vol. 696, # 1 p. 50 - 60

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Citation Number: 34

Abstract

In situ generated axially chiral zirconium biphenyl amidate complexes are efficient precatalysts for the enantioselective intramolecular hydroamination of aminoalkenes, generating α-substituted pyrrolidines and piperidine with up to 74% ee. Five new chelating amide proligands and three new zirconium amidate complexes have been prepared and fully characterized in this investigation of ligand structure/catalyst function. Solid-state ...