Synthesis and Crystal Structures of N, N′-Disubstituted Piperazines

JP Safko, RD Pike

Index: Safko, Jason P.; Pike, Robert D. Journal of Chemical Crystallography, 2012 , vol. 42, # 9 p. 981 - 987

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Citation Number: 2

Abstract

Abstract The structure of 1, 4-diphenylpiperazine (1) was determined; it crystallized in the orthorhombic space group Pbca, a= 8.6980 (7), b= 8.4287 (7), c= 17.6359 (15), V= 1292.94 (19), Z= 4. Three novel N, N′-disubstituted piperazines were synthesized via reductive amination of piperazine or N-diphenylmethylpiperazine. The products were characterized by NMR and X-ray crystallography. 1, 4-Diphenethylpiperazine (2) crystallized in the ...