Journal of medicinal chemistry

Folic acid analogs. Modifications in the benzene-ring region. 2. Thiazole analogs

EC Roberts, YF Shealy

Index: Roberts,E.C.; Shealy,Y.F. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 1310 - 1312

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Citation Number: 19

Abstract

Two thiazole analogs of folic acid, in which the benzene ring is replaced by a thiazole ring, were synthesized as part of a continuing program to design and obtain folic acid analogs with a potentially altered ability to function as one-carbon transfer agents. The reductive condensation of 2-acetamido-6-formylpteridin-4 (3H)-one (3) with diethyl N-[(2-amino-4- thiazolyl) carbonyl] glutamate (2) followed by hydrolysis of the blocking groups afforded ...