Organic letters

Mild Decarboxylative Activation of Malonic Acid Derivatives by 1, 1′-Carbonyldiimidazole

D Lafrance, P Bowles, K Leeman, R Rafka

Index: Lafrance, Danny; Bowles, Paul; Leeman, Kyle; Rafka, Robert Organic Letters, 2011 , vol. 13, # 9 p. 2322 - 2325

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Citation Number: 26

Abstract

Malonic acid derivatives undergo unusually mild decarboxylation when treated with N, N′- carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process.

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