Organocatalytic Synthesis of 1, 2, 3??Triazoles from Unactivated Ketones and Arylazides

M Belkheira, D El Abed, JM Pons…

Index: Belkheira, Mokhtaria; El Abed, Douniazad; Pons, Jean-Marc; Bressy, Cyril Chemistry - A European Journal, 2011 , vol. 17, # 46 p. 12917 - 12921

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Citation Number: 81

Abstract

The synthesis of 1, 2, 3-triazoles recently became popular with the copper-catalyzed version of the azide–alkyne Huisgen cycloaddition, developed independently by the groups of Sharpless [1a] and Meldal.[1b] While this powerful and highly regioselective reaction can be performed in various media by using several sources of copper or ruthenium catalysts,[2] it is usually restricted to terminal alkynes.[3] Another access to 1, 2, 3-triazoles is the highly ...