Preparation and in vitro antiprotozoan activity of new naphthoimidazolediones

…, F Delmas, M Gasquet, P Timon-David

Index: Vanelle; Donini; Maldonado; Crozet; Delmas; Gasquet; Timon-David European Journal of Medicinal Chemistry, 1997 , vol. 32, # 6 p. 523 - 528

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Citation Number: 7

Abstract

The original compound bearing the coplanar quinone and imidazole systems, 2- chloromethyl-4, 9-dihydro-1-rnethyl-1H-naphtho [2, 3-d] imidazol-4, 9-dione reacted with various nitronate anions to afford, in moderate to good yields, new naphthoimidazolediones bearing a trisubstituted ethylenic double bond at the 2-position. These compounds were evaluated as potential antiprotozoan agents. Some derivatives were found to have a ...