Journal of medicinal chemistry

Synthesis of nortriptyline and related compounds

LR Peters, GF Hennion

Index: Peters,L.R.; Hennion,G.F. Journal of Medicinal Chemistry, 1964 , vol. 7, p. 390 - 392

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Citation Number: 5

Abstract

The retent puhlication'of niethods for the synthesis of 3-substituted 5-(8-aminopropylidene)- lO, I l-dlhydro-5H-dibenzo-[a, d] ryrloheptenes, of which a number are useful psychotherapeutic drugs, prompts us to report a nex synthesis of one of these, nortriptyline CIS), using propargylic intermediates. The