Stable??isotope methodology for the bioavailability study of phenytoin during multiple??dosing regimens

…, K Mamada, S Baba, M Matsukura

Index: Kasuya; Mamada; Baba; Matsukura Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 5 p. 503 - 507

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Citation Number: 21

Abstract

Abstract With the highly sensitive and specific gas chromatographymass spectrometry (GC– MS), plasma concentrations resulting from an intravenous administration of only a small amount of stable isotopically labeled phenytoin (DPH-d 10) were determined to obtain information on the accurate clearance values under steady-state conditions attained with unlabeled phenytoin (DPH-d 0). A time course of DPH-d 10 concentrations was followed ...

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