Simple and efficient cleavage reaction of the boc group in heterocyclic compounds

K Nadia, B Malika, K Nawel, BM Yazid…

Index: Nadia, Klai; Malika, Berredjem; Nawel, Khettache; MedYazid, Belghit; Zine, Regainia; Aouf, Nour-Eddine Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 1 p. 57 - 60

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Citation Number: 22

Abstract

Abstract Dedicated to the memory of Pr. Ladjama Daif A series of chiral cyclosulfamides have been synthesized by alkaline cyclisation starting from N-benzoylamino acids (Ala, Val, Leu, Phe) derivatives and chlorosulfonyl isocyanate. A simplified and regioselective deprotection of the cyclic compounds (cyclosulfamides) containing the tert-butyloxycarbonyl group (Boc) has been achieved in good yield by fusion under reduced pressure.

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