The Reaction of Trimethylene Oxide with Amines1

S Searles, VP Gregory

Index: Searles; Gregory Journal of the American Chemical Society, 1954 , vol. 76, p. 2789

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Citation Number: 26

Abstract

The reaction of trimethylene oxide with amines in aqueous solution at room temperature is very slow, contrary to a previous report. At elevated temperatures, however, good yields of 3- hydroxypropylamines are obtained, from both primary and secondary amines, except when the latter is sterically hindered. The reaction of trimethylene oxide with alkyl and aryl bromomagnesium amides seems to be a general method of preparing such amino ...