Hypolipidemic analogs of ethyl 4-benzyloxybenzoate

KH Baggaley, R Fears, RM Hindley…

Index: Baggaley; Fears; Hindley; Morgan; Murrell; Thorne Journal of Medicinal Chemistry, 1977 , vol. 20, # 11 p. 1388 - 1393

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Citation Number: 23

Abstract

A series of compounds related to ethyl 4-benzyloxybenzoate was synthesized and evaluated for potential hypolipidemic activity in rats. Structure-activity relationships are discussed in terms of cholesterol-lowering activity together with effects on body weight gain and liver lipids. A number of the compounds inhibited cholesterol and free fatty acid biosynthesis from [l-14C] acetate in rat liver slices in vitro. Ethyl 4-benzyloxybenzoate, ...