Delayed fibril formation of amylin (20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis

AJ Brouwer, RC Elgersma, M Jagodzinska…

Index: Brouwer, Arwin J.; Elgersma, Ronald C.; Jagodzinska, Monika; Rijkers, Dirk T.S.; Liskamp, Rob M.J. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 78 - 84

Full Text: HTML

Citation Number: 12

Abstract

The synthesis of a new peptidomimetic structure, the alkene dipeptidosulfonamide isostere, is described. The synthesis is based on a cross metathesis reaction between two allylic building blocks, both in solution and on the solid phase. This method was also applicable to the solid phase synthesis of alkene dipeptide isosteres. Derivatives of amylin (20–29) containing the alkene dipeptidosulfonamide isostere as well as the alkene dipeptide ...

Related Articles:

BCl3??Mediated Ene Reaction of Sulfur Dioxide and Unfunctionalized Alkenes

[Markovic, Dean; Volla, Chandra M. R.; Vogel, Pierre; Varela-Alvarez, Adrian; Sordo, Jose A. Chemistry - A European Journal, 2010 , vol. 16, # 20 p. 5969 - 5975]

DABCO-bis (sulfur dioxide), DABSO, as a convenient source of sulfur dioxide for organic synthesis: utility in sulfonamide and sulfamide preparation

[Organic Letters, , vol. 13, # 18 p. 4876 - 4878]

Sulfonyl chloride formation from thiol derivatives by N-chlorosuccinimide mediated oxidation

[Nishiguchi, Atsuko; Maeda, Kazuhiro; Miki, Shokyo Synthesis, 2006 , # 24 p. 4131 - 4134]

Palladium-catalyzed desulfinylative C–C allylation of Grignard reagents and enolates using allylsulfonyl chlorides and esters

[Tetrahedron, , vol. 65, # 2 p. 504 - 511]

More Articles...