Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase

H Guan, AD Laird, RA Blake, C Tang…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 187 - 190

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Citation Number: 43

Abstract

... Bioorganic & Medicinal Chemistry Letters. Volume 14, Issue 1, 5 January 2004, Pages 187–190. ... Our chemistry efforts were focused on (1) the C-5 position of the oxindole ring, (2) the tetrahydroindole moiety and (3) the 3′-amino side chain as shown in Figure 1. ...

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