Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives

…, V Weber, MJ Galmier, M Borel, M Madesclaire…

Index: Reux, Bastien; Weber, Valerie; Galmier, Marie-Josephe; Borel, Michele; Madesclaire, Michel; Madelmont, Jean-Claude; Debiton, Eric; Coudert, Pascal Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 9 p. 5004 - 5020

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Citation Number: 37

Abstract

Frequently used in the treatment of malignant cells, alkylating agents, like most anticancer substances, produce adverse side effects caused by the toxicity of the agents toward normal tissues and lose efficiency through poor distribution to target sites. Our approach to developing more selective drugs with low systemic toxicity is based on the premise that the body distribution and cell uptake of a drug can be altered by attaching a neoplastic cell- ...

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