SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor

Y Leblanc, P Roy, S Boyce, C Brideau, CC Chan…

Index: Leblanc; Roy; Boyce; Brideau; Chan; Charleson; Gordon; Grimm; Guay; Leger; Li; Riendeau; Visco; Wang; Webb; Xu; Prasit Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2207 - 2212

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Citation Number: 45

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied. ... DFP was found to be a ...