Two-enzyme coexpressed recombinant strain for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate

…, NI Ye, W Junchao, XU Zhihao, SUN Zhihao

Index: Su, Yuning; Ni, Ye; Wang, Junchao; Xu, Zhihao; Sun, Zhihao Chinese Journal of Catalysis, 2012 , vol. 33, # 9-10 p. 1650 - 1660

Full Text: HTML

Citation Number: 4

Abstract

(R)-2-Hydroxy-4-phenylbutyrate (HPBE) is an important chiral intermediate for the synthesis of angiotensin-converting enzyme (ACE) inhibitors. Asymmetric reduction of ethyl 2-oxo-4- phenyl-butyrate (OPBE) to (R)-HPBE using a recombinant strain can provide high enantioselectivity. Cofactor regeneration is a critical issue in the application of a recombinant strain. A carbonyl reductase gene (iolS) and a glucose dehydrogenase (GDH ...

Related Articles:

Angiotensin-converting enzyme inhibitors. Perhydro-1, 4-thiazepin-5-one derivatives

[Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 1984 - 1991]

Heterogeneous Enantioselective Hydrogenation of Activated Ketones Catalyzed by Modified Pt??Catalysts: A Systematic Structure??Selectivity Study

[Advanced Synthesis and Catalysis, , vol. 345, # 11 p. 1253 - 1260]

Facile synthesis of (S)-β-hydroxy-β-trichloromethylated aromatic ketones by the regioselective ring cleavage of chiral β-trichloromethyl-β-propiolactone under the …

[Tetrahedron Letters, , vol. 38, # 9 p. 1593 - 1596]

Enantio-complementary deracemization of (±)-2-hydroxy-4-phenylbutanoic acid and (±)-3-phenyllactic acid using lipase-catalyzed kinetic resolution combined with …

[Larissegger-Schnell, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt Tetrahedron, 2006 , vol. 62, # 12 p. 2912 - 2916]

Enantioselective Organocatalytic Rearrangement of α??Acyloxy?螃漫?keto Sulfides to α??Acyloxy Thioesters

[Capitta, Francesca; Frongia, Angelo; Piras, Pier Paolo; Pitzanti, Patrizia; Secci, Francesco Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2955 - 2960]

More Articles...