Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives
JAS Mulla, MIA Khazi, SI Panchamukhi…
Index: Mulla, Jameel Ahmed S.; Khazi, Mohammed Iqbal A.; Panchamukhi, Shridhar I.; Gong, Young-Dae; Khazi, Imtiyaz Ahmed M. Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3235 - 3243
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Citation Number: 3
Abstract
Abstract Novel tricyclic thienopyrimidines (2, 3, 5, 8) and triazole-fused tetracyclic thienopyrimidines (6a–c and 9a–c) were synthesized from the precursor 2-amino-4, 5, 6, 7- tetrahydro-1-benzothiophene-3-carbonitrile (1). The structures of newly synthesized compounds were established by spectral and analytical data. The title compounds were screened for analgesic, anti-inflammatory, ulcerogenicity index, and antibacterial activities ...
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