Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives

JAS Mulla, MIA Khazi, SI Panchamukhi…

Index: Mulla, Jameel Ahmed S.; Khazi, Mohammed Iqbal A.; Panchamukhi, Shridhar I.; Gong, Young-Dae; Khazi, Imtiyaz Ahmed M. Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3235 - 3243

Full Text: HTML

Citation Number: 3

Abstract

Abstract Novel tricyclic thienopyrimidines (2, 3, 5, 8) and triazole-fused tetracyclic thienopyrimidines (6a–c and 9a–c) were synthesized from the precursor 2-amino-4, 5, 6, 7- tetrahydro-1-benzothiophene-3-carbonitrile (1). The structures of newly synthesized compounds were established by spectral and analytical data. The title compounds were screened for analgesic, anti-inflammatory, ulcerogenicity index, and antibacterial activities ...

Related Articles:

Studies on the synthesis and interconversion of isomeric triazolothienopyrimidines. Part III. Cyclization reactions of 2??amino??3??(1H??1, 2, 4??triazol??3??yl) thiophenes

[Shishoo, C. J.; Devani, M. B.; Ullas, G. V.; Ananthan, S.; Bhadti, V. S. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1125 - 1131]

Studies in the synthesis and interconversion of isomeric triazolothienopyrimidines

[Shishoo, C. J.; Devani, M. B.; Ullas, G. V.; Anathan, S.; Bhadti, V. S. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 43 - 46]

Studies in the synthesis and interconversion of isomeric triazolothienopyrimidines

[Shishoo, C. J.; Devani, M. B.; Ullas, G. V.; Anathan, S.; Bhadti, V. S. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 43 - 46]

Studies in the synthesis and interconversion of isomeric triazolothienopyrimidines

[Shishoo, C. J.; Devani, M. B.; Ullas, G. V.; Anathan, S.; Bhadti, V. S. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 43 - 46]

Studies in the synthesis and interconversion of isomeric triazolothienopyrimidines

[Shishoo, C. J.; Devani, M. B.; Ullas, G. V.; Anathan, S.; Bhadti, V. S. Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 43 - 46]

More Articles...