New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

…, F Tombret, G Cuvier, A Marivain, JM Gillardin

Index: Lepage; Tombret; Cuvier; Marivain; Gillardin European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593

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Citation Number: 64

Abstract

Abstract We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The disubstitution in the 2.6-position on the phenyl ring by two methyl groups would appear to be of primary importance for the activity. The amide bridge between the phenyl and isoxazolic ...