Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

…, RF Hall, X Lin, S Livia, T Respondek, KL Widdowson…

Index: Wan, Zehong; Yan, Hongxing; Hall, Ralph F.; Lin, Xichen; Livia, Stefano; Respondek, Tomasz; Widdowson, Katherine L.; Zhu, Chongjie; Callahan, James F. Tetrahedron Letters, 2009 , vol. 50, # 3 p. 370 - 372

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Citation Number: 3

Abstract

Chemoselectivity of chlorine versus methylthio (–SCH3), methylsulfinyl (–SOCH3), or methylsulfonyl [–S (O) 2CH3] in either functionalization or substitution of pyridopyrimidinone and pyrimidopyrimidinone was studied. Utilization to prepare final targets for accelerated SAR studies via two-dimensional array syntheses has been demonstrated in both systems.