Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1

…, S James, M Henriksson, L Johansson, C Kaiser…

Index: Sutin, Lori; Andersson, Soeren; Bergquist, Lars; Castro, Victor M.; Danielsson, Eva; James, Stephen; Henriksson, Martin; Johansson, Lars; Kaiser, Christina; Flyren, Katarina; Williams, Meredith Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4837 - 4840

Full Text: HTML

Citation Number: 30

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... 2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure–activity relationship and metabolic stability of these compounds are presented. ... Compounds of general formula 1 were found to be potent inhibitors of ...