Diaminodiacid??Based Solid??Phase Synthesis of Peptide Disulfide Bond Mimics

…, Y He, FL Wang, HN Chang, YJ Wang…

Index: Cui, Hong-Kui; Guo, Ye; He, Yao; Wang, Feng-Liang; Chang, Hao-Nan; Wang, Yu-Jia; Wu, Fang-Ming; Tian, Chang-Lin; Liu, Lei Angewandte Chemie - International Edition, 2013 , vol. 52, # 36 p. 9558 - 9562 Angew. Chem., 2013 , vol. 125, # 36 p. 9737 - 9741,5

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Citation Number: 25

Abstract

Intensive research has recently been conducted on the development of conformation- rigidified peptidic macrocycles for diagnostic and therapeutic applications.[1] These compounds usually exhibit extraordinary thermal and metabolic stability owing to their defined tertiary folding constrained by one or multiple disulfide bridges.[2] A potential problem for the application invivo is that the disulfide bridges are unstable towards ...

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