Synthesis and characterization of various unsubstituted and mono-N-substituted tetraazamacrocycles

…, AK Mishra, B Hanquet, R Guilard…

Index: Meunier, I.; Mishra, A. K.; Hanquet, B.; Cocolios, P.; Guilard, R. Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 685 - 695

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Citation Number: 42

Abstract

Syntheses of tetraazamacrocycles have been carried out by using p-toluenesulfonyl chloride as protective group. The [14 (ane) N4] and [15 (ane) N4] were also obtained by the template synthesis. Mono-N-functionalization of tetraazamacrocycles was accomplished by reaction of a fivefold excess of the free macrocycles with 1 equivalent of a suitable alkylating or arylating reagent. The key point of the synthesis lies in the use of an excess of the ...