5-Arylethynyl-2′-deoxyuridines, compounds active against HSV-1

MV Skorobogatyi, AV Ustinov, IA Stepanova…

Index: Skorobogatyi, Mikhail V.; Ustinov, Alexei V.; Stepanova, Irina A.; Pchelintseva, Anna A.; Petrunina, Anna L.; Andronova, Valeriya L.; Galegov, Georgi A.; Malakhov, Andrei D.; Korshun, Vladimir A. Organic and Biomolecular Chemistry, 2006 , vol. 4, # 6 p. 1091 - 1096

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Citation Number: 25

Abstract

Three new 5-arylethynyl-2′-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2′-deoxyuridine, leads to the appearance of anti- HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2′-deoxyuridine through a rigid triple ...