Direct Electrophilic Silylation of Terminal Alkynes

…, NV Komarov, M Rubin, C Brouwer, V Gevorgyan

Index: Andreev, Aleksey A.; Konshin, Valeri V.; Komarov, Nikolai V.; Rubin, Michael; Brouwer, Chad; Gevorgyan, Vladimir Organic Letters, 2004 , vol. 6, # 3 p. 421 - 424

Full Text: HTML

Citation Number: 24

Abstract

A variety of alkynylsilanes were efficiently prepared via direct silylation of terminal alkynes with aminosilanes in the presence of zinc halides. Base-and nucleophile-sensitive functionalities were perfectly tolerated under the above reaction conditions. Initial mechanistic studies support the electrophilic character of this transformation.