Designing N??Heterocyclic Carbenes: Simultaneous Enhancement of Reactivity and Enantioselectivity in the Asymmetric Hydroacylation of Cyclopropenes

…, X Bugaut, M Schedler, R Fröhlich…

Index: Liu, Fan; Bugaut, Xavier; Schedler, Michael; Froehlich, Roland; Glorius, Frank Angewandte Chemie - International Edition, 2011 , vol. 50, # 52 p. 12626 - 12630

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Citation Number: 65

Abstract

Since their initial use in benzoin condensation,[1] N-heterocyclic carbenes (NHCs) have become widely utilized as organocatalysts in forging challenging CÀC bonds.[2] Our laboratory has dedicated efforts to utilize electron-neutral multiple bonds as unconventional reaction partners in organocatalysis.[3, 4] We recently reported the first NHC-catalyzed intermolecular hydroacylation reaction of electron-neutral olefins using cyclopropenes as ...

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