Hypoxia-selective agents derived from quinoxaline 1, 4-di-N-oxides

…, JA Palop, AL de Cerain, V Senador…

Index: Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792

Full Text: HTML

Citation Number: 134

Abstract

Hypoxic cells, which are a common feature of solid tumors, but not normal tissues, are resistant to both anticancer drugs and radiation therapy. Thus the identification of drugs with selective toxicity toward hypoxic cells is an important objective in anticancer chemotherapy. The benzotriazine di-N-oxide (SR 4233, Tirapazamine) has been shown to be an efficient and selective cytotoxin for hypoxic cells. Since the bioreductive activation of Tirapazamine ...

Related Articles:

Revised Students' Check-List of Texts Illustrating the History of Medicine

[Reverdin Chemische Berichte, 1909 , vol. 42, p. 1526 Chem. Zentralbl., 1909 , vol. 80, # I p. 1810]

Structural and Electrochemical Studies of Co (III) Cage Amine Complexes with Pendent Thienylmethylamino Groups

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

Structural and Electrochemical Studies of Co (III) Cage Amine Complexes with Pendent Thienylmethylamino Groups

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

Structural and Electrochemical Studies of Co (III) Cage Amine Complexes with Pendent Thienylmethylamino Groups

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

Structural and Electrochemical Studies of Co (III) Cage Amine Complexes with Pendent Thienylmethylamino Groups

[Galliani, Guido; Rindone, Bruno Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 828 - 832]

More Articles...