Tetrahedron letters

Synthesis of linoleic acids combinatorially labeled at the vinylic positions as substrates for lipoxygenases

MP Meyer, JP Klinman

Index: Meyer, Matthew P.; Klinman, Judith P. Tetrahedron Letters, 2008 , vol. 49, # 22 p. 3600 - 3603

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Citation Number: 9

Abstract

Mammalian lipoxygenases have been implicated in a number of inflammation-related human diseases. Soybean lipoxygenase-1 is the archetypical example of known lipoxygenases. Here we report the synthesis of linoleic acid and (11, 11)-d2-linoleic acid which are combinatorially labeled at the vinylic positions (9, 10, 12, and 13). Combinatorial labeling schemes allow for the simultaneous determination of KIEs in enzymatic reactions ...