Dehydrative C–H Alkylation and Alkenylation of Phenols with Alcohols: Expedient Synthesis for Substituted Phenols and Benzofurans

DH Lee, KH Kwon, CS Yi

Index: Lee, Dong-Hwan; Kwon, Ki-Hyeok; Yi, Chae S. Journal of the American Chemical Society, 2012 , vol. 134, # 17 p. 7325 - 7328

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Citation Number: 95

Abstract

A well-defined cationic Ru–H complex catalyzes the dehydrative C–H alkylation reaction of phenols with alcohols to form ortho-substituted phenol products. Benzofuran derivatives are efficiently synthesized from the dehydrative C–H alkenylation and annulation reaction of phenols with 1, 2-diols. The catalytic C–H coupling method employs cheaply available phenols and alcohols, exhibits a broad substrate scope, tolerates carbonyl and amine ...

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