Sulfoconjugation of dopamine. A critical examination of the reaction between dopamine and concentrated sulfuric acid

…, C Kaiser, DM Ackerman, DL Ladd…

Index: Jain, Tikam; Kaiser, Carl; Ackerman, Dennis M.; Ladd, David L.; Fong, Kei-Lai; et al. Canadian Journal of Chemistry, 1986 , vol. 64, p. 2418 - 2422

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Citation Number: 4

Abstract

Dopamine, a physiologically important biogenic amine, is readily sulfoconjugated in vivo to give the 3-and 4-O-sulfates of pharmacologic importance. A major synthetic source of these esters has involved reaction of dopamine with sulfuric acid; however, the homogeneity of the products of this apparently straightforward reaction has been questioned. For this reason, in the present study this reaction was studied in considerable detail and our results establish ...