Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells

MK Purohit, I Scovell, A Neschadim, Y Katsman…

Index: Purohit, Meena K.; Scovell, Iain; Neschadim, Anton; Katsman, Yulia; Branch, Donald R.; Kotra, Lakshmi P. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 8 p. 2324 - 2327

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Citation Number: 10

Abstract

Immune thrombocytopenia (ITP) is caused by production of an autoantibody to autologous platelets. ITP can be treated either by reducing platelet destruction or by increasing platelet production. Fcγ receptor mediated phagocytosis of the opsonized blood cells is a well- accepted mechanism for the underlying pathogenesis of ITP and inhibition of this phagocytosis process with small molecules is a potential strategy for the development of ...