Absolute configuration of the four stereoisomers of valnoctamide (2-ethyl-3-methyl valeramide), a potentially new stereospecific antiepileptic and CNS drug

M Roeder, O Spiegelstein, V Schurig, M Bialer…

Index: Roeder, Michael; Spiegelstein, Ofer; Schurig, Volker; Bialer, Meir; Yagen, Boris Tetrahedron Asymmetry, 1999 , vol. 10, # 5 p. 841 - 853

Full Text: HTML

Citation Number: 20

Abstract

Valnoctamide (2-ethyl-3-methyl valeramide, Nirvanil®, VCD), a mild tranquilizer endowed with anticonvulsant properties, exhibits diastereoselective and enantioselective pharmacokinetics in healthy subjects and epileptic patients. The purpose of this paper is to assign the absolute configuration of the four VCD stereoisomers and to describe the stereoselective synthesis used to prepare two-key VCD stereoisomers. We have ...

Related Articles:

Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates

[Kawamura, Shuhei; Unno, Yuka; Asai, Akira; Arisawa, Mitsuhiro; Shuto, Satoshi Organic and Biomolecular Chemistry, 2013 , vol. 11, # 38 p. 6615 - 6622]

Highly diastereoselective 1, 4-addition of an organocuprate to methyl α-D-gluco-, α-D-manno-, or α-D-galactopyranosides tethering an α, β-unsaturated ester. Novel …

[Rueck, Karola; Kunz, Horst Synthesis, 1993 , # 10 p. 1018 - 1028]

More Articles...