(2-Naphthyl) glycolic acid: a tailored resolving agent for p-substituted 1-arylethylamines

K Kinbara, Y Harada, K Saigo

Index: Kinbara, Kazushi; Harada, Yoshiko; Saigo, Kazuhiko Tetrahedron Asymmetry, 1998 , vol. 9, # 13 p. 2219 - 2222

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Citation Number: 20

Abstract

A tailored resolving agent for p-substituted 1-arylethylamines, which was designed on the basis of a criterion derived from our crystal-structure study, namely that the racemate and the resolving agent should have similar molecular lengths, is described. The designed enantiopure (2-naphthyl) glycolic acid (2-NGA) showed excellent resolving ability for a wide variety of p-substituted 1-arylethylamines.