Synthetic Communications®

Method for Regio-and Stereoselective Synthesis of (E)-β, γ-Unsaturated Acids from Aldehydes Under Solvent-Free Conditions

SJ Zhang, WX Hu

Index: Zhang, Shi-Jie; Hu, Wei-Xiao Synthetic Communications, 2010 , vol. 40, # 20 p. 3093 - 3100

Full Text: HTML

Citation Number: 2

Abstract

Synthesis of (E)-β, γ-unsaturated acids from aldehydes with malonic acid has been explored under solvent-free conditions. The modified Knoevenagel condensation reaction with N- methyl morpholine (NMM) as catalyst exhibits highly β, γ-regioselectivity and exclusively E-

Related Articles:

Free-radical-mediated carbonylative cyclisation of alk-4-enyl halides leading to cyclopentanones

[Ryu, Ilhyong; Kusano, Kazuya; Hasegawa, Mitsuharu; Kambe, Nobuaki; Sonoda, Noboru Journal of the Chemical Society, Chemical Communications, 1991 , # 15 p. 1018 - 1019]

The preparation of some cyclic phosphonates and their use in olefin synthesis

[Breuer,E.; Bannet,D.M. Tetrahedron, 1978 , vol. 34, p. 997 - 1002]

Chemistry of acetylenic ethers 84: Addition of aldehydes, ketones, esters and amides to 1??alkynyl ethers under the influence of Lewis acids; direct formation of α, β?? …

[Vieregge,H. et al. Recueil des Travaux Chimiques des Pays-Bas, 1966 , vol. 85, p. 929 - 951]

Umsetzung von Alkylidenphosphoranen mit Estern von α??Halogenessigsäuren

[Bestmann,H.J. et al. Angewandte Chemie, 1966 , vol. 78, p. 335]

361. The chemistry of the three-carbon system. Part XXIX. Tautomerism of unsaturated esters

[Kon; Linstead; Maclennan Journal of the Chemical Society, 1932 , p. 2457]

More Articles...