Highly stereoselective conversion of aryl peptidyl ketones into the corresponding peptide alcohols

…, A Le Pera, A Liguori, C Siciliano

Index: Di Gioia, Maria Luisa; Leggio, Antonella; Le Pera, Adolfo; Liguori, Angelo; Siciliano, Carlo European Journal of Organic Chemistry, 2004 , # 3 p. 463 - 467

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Citation Number: 4

Abstract

Abstract In this paper we describe the conversion of aryl peptidyl ketones, by a hydride reduction, into the corresponding peptide alcohols. The developed methodology is highly stereoselective and represents a very important application in peptide chemistry for obtaining peptide alcohols. It provides peptide alcohols with definite stereochemistry and in moderate, but satisfactory, yields. The reducing procedure, performed with NaBH 3 CN ...

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