A practical enzymatic procedure for the resolution of N-substituted 2-azabicyclo [2.2. 1] hept-5-en-3-one

M Mahmoudian, A Lowdon, M Jones, M Dawson…

Index: Mahmoudian, Mahmoud; Lowdon, Andrew; Jones, Martin; Dawson, Michael; Wallis, Christopher Tetrahedron Asymmetry, 1999 , vol. 10, # 6 p. 1201 - 1206

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Citation Number: 35

Abstract

A simple and efficient process for the enantioselective resolution of N-substituted 2- azabicyclo [2.2. 1] hept-5-en-3-one has been developed using commercially available hydrolytic enzymes. This offers a practical approach for the preparation of enantiomerically pure N-substituted γ-lactams.