Stereochemical dynamics of aliphatic hydroxylation by cytochrome P-450

…, JP Miller, LV Favreau, A Bhattacharyya

Index: White, Ronald E.; Miller, John P.; Favreau, Leonard V.; Bhattacharyya, Apares Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6024 - 6031

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Citation Number: 127

Abstract

Abstract: Previous studies on the stereochemistry of hydroxylation by cytochrome P-MO enzymes have been contradictory and confusing. Therefore, the hydroxylation of four isotopically substituted phenylethane substrates has been examined with a single isozyme of rabbit liver microsomal cytochrome P-450. In each case the corresponding 1- phenylethanol was essentially the only product. With ordinary phenylethane, the product ...