Low??energy collision??induced fragmentation of negative ions derived from diesters of aliphatic dicarboxylic acids made with hydroxybenzoic acids

U Nishshanka, AB Attygalle

Index: Nishshanka, Upul; Attygalle, Athula B. Journal of Mass Spectrometry, 2008 , vol. 43, # 11 p. 1502 - 1511

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Citation Number: 6

Abstract

Abstract Diesters of ortho-hydroxybenzoic acid (salicylic acid) made with glutaric, adipic, and pimelic acids are the monomers of some potential drug candidates for aspirin patches. Collision-induced dissociation (CID) spectra of negative ion derived from these compounds show a 120-Da 'neutral loss' specific to the ortho isomers. In contrast, the anions derived from diesters of meta-and para-hydroxybenzoic acids show a 138-Da loss for an ...