The chemical development of the commercial route to sildenafil: a case history

…, AK Pearce, PM Searle, G Ward, AS Wood

Index: Dale, David J.; Dunn, Peter J.; Golightly, Clare; Hughes, Michael L.; Levett, Philip C.; Pearce, Andrew K.; Searle, Patricia M.; Ward, Gordon; Wood, Albert S. Organic Process Research and Development, 2000 , vol. 4, # 1 p. 17 - 22

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Citation Number: 123

Abstract

This paper is a case history of the chemical development of sildenafil which covers various aspects of work in chemical development namely: route selection, scale-up issues, the development of an efficient synthesis with high throughput, process safety, and environmental issues. Interesting chemical points include improved methods of preparing pyrazolo [4, 3-d] pyrimidines and the unusual isolation of an intermediate as its double salt ...