Enantiopure β 3-neopentylglycine: synthesis and resolution

…, M Arnold, S Peter, I Troltsch, S Merget, F Glaser…

Index: ter Wiel, Matthijs K.J.; Arnold, Mirjam; Peter, Sandra; Troltsch, Ingo; Merget, Stefan; Glaser, Florian; Schwarm, Michael; Bhatti, Harjinder S.; Kuriakose, Biju; Pol, Suryakant S.; Balamurugan, Mohanasundaram; Joshi, Viral V. Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 478 - 482

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Citation Number: 4

Abstract

A procedure has been developed for the large scale synthesis of enantiopure β3- neopentylglycine and its Cbz-protected derivative. The synthetic route developed in our laboratory features Cbz-protection of the racemic β-amino acid followed by resolution with l- norephedrine and provides the enantiomerically pure Cbz-β-neopentylglycine in good yield and excellent enantiopurity. No toxic or dangerous chemicals are used, allowing the scale ...