Chemical confirmation of the structure of a mutagenic aminophenylnorharman, 9-(4'-aminophenyl)-9H-pyrido [3, 4-b] indole

…, N Imai, T Miura, T Sugimura, K Wakabayashi…

Index: Murakami, Yasuoki; Imai, Nobuyuki; Miura, Tsuyoshi; Sugimura, Takashi; Wakabayashi, Keiji; Totsuka, Yukari; Hada, Noriyasu; Yokoyama, Yuusaku; Suzuki, Hideharu; Mitsunaga, Katsuyoshi Heterocycles, 2010 , vol. 80, # 1 p. 455 - 462

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Abstract

Abstract 9-(4'-Aminophenyl)-9H-pyrido [3, 4-b] indole 2 is a mutagenic compound produced by non-mutagenic norharman 1 and aniline in the presence of S9 mix. 9-(4'-Nitrophenyl)-9H- pyrido [3, 4-b] indole 4, the relay compound for synthesis of 2, was synthesized starting from ethyl indole-2-aldehyde 12 via initial N-(4-nitro) phenylation of the indole nucleus, elongation of the 2-aldehyde substituent, and then construction of the pyridine nucleus in ...